Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Antioxidants and Procarbazine

supplement:

Antioxidants

Research Papers that Mention the Interaction

However, both the antioxidant enzymes activities were significantly inhibited in muscle of fish exposed to 500 microg L(-1) PCZ after 30 d. Moreover there was significant lower RNA/DNA ratio in both tissues after long-term exposure to higher concentration of PCZ.
Ecotoxicology and environmental safety  •  2010  |  View Paper
These results indicate a decrease in the toxicity of procarbazine when coadministered with antioxidants , via decreased spermatotoxicity without changing anticancer efficacy.
Thus, protection against the spermatotoxic effects of procarbazine was demonstrated with either antioxidant.
Two antioxidants , N-acetylcysteine and sodium ascorbate, administered with equimolar doses of procarbazine decreased the spermatotoxicity of procarbazine.
Cancer research  •  1987  |  View Paper