Possible Interaction: Antioxidants and Probucol

“ PB loaded in mesoporous particle was shown to enhance the antioxidant response to extracellular ROS in the endothelial cell line model, and to intracellular ROS in the microglia cell model.”

“Preincubation of LDL with the antioxidant probucol before injection markedly decreased the expression of TNF-&agr; immunoreactivity.”

“Pretreatment of the animals with the antioxidants probucol or N-acetylcysteine (NAC) prevented the generation of TBARS in the gingiva.”

“The effectiveness of antioxidants as inhibitors of LDL oxidation decreased in the following order: desferal > probucol > K-phenosan, and antihypoxant ability was decreased in line: deltaran >> succinic acid (effect only in dose 40 mg/ml) >> hypoxane (no effect).”

“ Probucol depressed the toxicity most effectively among the antioxidants studied under both pretreatment and concurrent treatment conditions.”

“Suppression of lipid peroxidation in LDL by probucol and other antioxidants (ascorbate, 6-O-palmitoylascorbate, and ubiquinol-10) prevents the formation of probucol radical.”

“However, a major result of the study — that probucol alone is effective, but that high-dose antioxidant vitamins themselves have no activity and, when added to probucol , may even impair the therapeutic effects of the drug — strongly argues against that basic assumption.”

“Additionally we demonstrated that the addition of probucol , a powerful antioxidant used clinically to lower blood cholesterol, inhibited this copper-catalyzed oxidation of cholesterol.”

“However, whereas co-incubation with physiologic levels of ascorbate resulted in a substantial preservation of the alpha-tocopherol, gamma-tocopherol, and beta-carotene of the LDL, probucol in concentrations ranging from 10 to 80 microM failed to protect these antioxidants.”

“ Probucol lessened the HFD-induced elevation of serum TNF-α and hepatic malondialdehyde and reduced antioxidant enzymatic activities.”