Possible Interaction: Antioxidants and Phospholipids

“It has been reported that phospholipids can act as agents to improve the absorption of antioxidants.”

“ Antioxidant treatment prevented light-induced phospholipid oxidation and the subsequent increase of monocyte chemoattractant protein-1 (also known as C-C motif chemokine 2; CCL2), which are the beginnings of the light-induced changes.”

“Pretreatment of either human or bovine erythrocytes with antioxidants such as vitamin E (2 mM) prevented both oxidant‐induced reorganization of phospholipids in the bilayer and enhancement of adherence to endothelial cells.”

“ Antioxidants play an important role in the regulation of phospholipid hydrolysis and arachidonate metabolism.”

“The results obtained with FENIX afford an excellent correlation with anti-ferroptotic potency, which … characterization of ferroptosis inhibitors, and reveals the importance of H-bonding interactions between antioxidant … phospholipid that underlie both the lackluster antioxidant activity of phenols under … conditions and the emergence of arylamines as inhibitors of choice.”

“While dietary antioxidants are believed to help prevent these diseases via inhibition of phospholipid peroxidation , further evaluation is needed to prove this hypothesis.”

“In parallel, the GB extract significantly increased the total antioxidant plasma capacity (by 24.5% TRAP; 27.9% FRAP) only when complexed with phospholipids.”

“In a phospholipid‐containing system , an ADP:Fe2+ complex induced both lipid peroxidation and protein carbonyl formation; both indices were largely inhibitable by antioxidants.”

“The activities of the three key enzymatic antioxidant defenses , SOD, GPx and GST, increased with the degree of unsaturation of the phospholipid fatty acids.”

“The accelerated turnover of cardiomyocyte‐membrane protein and phospholipid was inhibited by antiperoxidants , suggesting that the turnover reflected molecular repair of oxidized membrane constituents.”