Possible Interaction: Antioxidants and Phenytoin

“The activation of HGFs by phenytoin was markedly reduced in the presence of antioxidant vitamins : ascorbic acid, folic acid, and α-tocopherol.”

“Both classical analgesics (…, paroxetine, escitalopram, phenytoin or … antioxidant processes in the mammalian tissues and these properties of drugs such as indomethacin, meloxicam, tenoxicam, valdecoxib or some metabolites of analgesic … efficacy and drug-related toxic effects, including gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”