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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Antioxidants
supplement:
Phenylalanine
Research Papers that Mention the Interaction
“ Phenylalanine (Phe) reduces antioxidant defense and promotes oxidative stress by causing increase in reactive oxygen-nitrogen species.”
Studying the effect of large neutral amino acid supplements on oxidative stress in phenylketonuric patients“Furthermore, increased phenylalanine levels, and its metabolites, may enhance the endogenous synthesis of reactive species and free radicals and/or interfere with the endogenous synthesis of enzymatic antioxidants (like glutathione peroxidase).”
“In conclusion, exposition to high phenylalanine concentrations for a short or long time results in a reduction of non‐enzymatic and enzymatic antioxidant defenses , whereas protein and lipid oxidative damage only occurs in patients with late diagnosis.”
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