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Journal of pediatric endocrinology & metabolism : JPEM • 2019 | View Paper
“Furthermore, increased phenylalanine levels, and its metabolites, may enhance the endogenous synthesis of reactive species and free radicals and/or interfere with the endogenous synthesis of enzymatic antioxidants (like glutathione peroxidase).”
Journal of Inherited Metabolic Disease • 2011 | View Paper
“In conclusion, exposition to high phenylalanine concentrations for a short or long time results in a reduction of non‐enzymatic and enzymatic antioxidant defenses , whereas protein and lipid oxidative damage only occurs in patients with late diagnosis.”