Possible Interaction: Antioxidants and Paclitaxel

“Nine phenolic antioxidants ((+)-catechin, (-)-epicatechin, fisetin, gallic acid, morin, myricetin, naringenin, quercetin and resveratrol) were tested for inhibition of paclitaxel metabolism.”

“ Antioxidants , including N-acetylcysteine and polyethylene glycol-conjugated catalase and superoxide dismutase, inhibited the toxicity of 2DG + PTX and suppressed parameters indicative of oxidative stress in cancer cells, whereas inhibition of glutathione synthesis using BSO further sensitized breast cancer cells to 2DG + PTX.”

“Modulating the oxidant antioxidant status of tumour cells may increase the antitumour activity of paclitaxel.”

“We have also reported that a mixture of three antioxidants statistically signifi cantly enhanced paclitaxel and carboplatin – induced apoptosis in a human lung squamous cancer cell line ( 4 ).”

“Combining antioxidants and paclitaxel has significant potential to overcome the risk of paclitaxel resistance.”

“ Paclitaxel significantly (p < .05) increased nitric oxide, decreased total antioxidant capacity and reduced testosterone levels than control group.”

“The neuronal death induced by taxol was significantly attenuated not only by anti-apoptotic drugs such as z-VAD-fmk and cycloheximide but also by antioxidants such as trolox, ascorbic acid and tempol.”

“The data suggest that the angiogenic response to cisplatin, cyclophosphamide, fluorouracil and paclitaxel was significantly influenced by the presence of antioxidants in the vehicles or when co-treated with N-acetylcystein, a widely used free-radical scavenger.”

“20067 Background: We … earlier demonstrated that antioxidants (beta carotene, vitamins C and …) enhance the apoptotic effect of paclitaxel and carboplatin in vitro and there was a suggestion that when used as an adjunct to … above chemotherapeutic agents in patients with NSCLC, they might enhance the efficacy of the latter.”