supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Oltipraz
Research Papers that Mention the Interaction
“Our results show for the first time that OPZ significantly alters the expression of human genes within different functional categories (detoxification of xenobiotics, antioxidant defences , xenobiotic transport, cell cycle and stress responses), at both the mRNA and protein levels, some of which are highly relevant to chemoprevention.”
Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.“Moreover, OPZ treatment remarkably increased the levels of antioxidant markers such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) in ISO-induced HF rats.”
Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response.“The administration of the dithiolthione antioxidant oltipraz (30 mg/kg/day for 10 days) resulted in a significant decrease (47%) in the incidence of TCDD-induced DNA-SSB.”
“Both sulforaphane and oltipraz increased the expression of anti-oxidant genes GCLC and NQO1.”
Nrf2 activators as potential modulators of injury in human kidney cells
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback