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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Norethindrone
Research Papers that Mention the Interaction
“Metabolomic analysis showed that … processes responsible for antioxidant defence were … NET (e.g. upregulation of nervonyl carnitine and chenodeoxycholic acid 3-sulfate; downregulation of homolanthionine and acevaltrate) and these changes … antioxidant defence by suppressing Nrf2-ARE and NF-κB pathways that contribute to the synthesis of SOD and GSH.”
“While acute mortality …, we found that antioxidant defence was … by NET at 500 ng/L (i.e. reduced SOD and GSH levels) and hence liver injury was inflicted (i.e. … and MDA levels), as manifested by vacuolization of liver tissues and reduced number of normal cells in the liver.”
Norethindrone causes cellular and hepatic injury in zebrafish by compromising the metabolic processes associated with antioxidant defence: Insights from metabolomics.
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