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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Antioxidants and Norepinephrine

Research Papers that Mention the Interaction

Carvedilol and several of its metabolites are potent antioxidants that may inhibit catecholamine toxicity resulting from the oxidation of norepinephrine and the subsequent formation of toxic intermediates, including the generation of reactive oxygen free radicals in the myocardium.
The American journal of cardiology  •  1997  |  View Paper
Noradrenaline concentrations were associated with higher antioxidant concentrations.
British Journal of Sports Medicine  •  2004  |  View Paper
Importantly, carvedilol and several of its metabolites are potent antioxidants that may inhibit the oxidation of norepinephrine and the subsequent formation of toxic intermediates, such as reactive free radicals in the myocardium.
American journal of hypertension  •  1998  |  View Paper
The results obtained show that NE administration influences the antioxidant cellular defence system significantly increasing glutathione peroxidase (GPx) activity, glutathione reductase (GR) and superoxide dismutase (SOD).
Journal of cellular and molecular medicine  •  2007  |  View Paper
Antioxidant vitamins reduce cardiac oxidative stress and cardiomyocyte apoptosis produced by exogenous norepinephrine ( NE ) and attenuate cardiac dysfunction in animals with pacing-induced congestive heart failure (CHF).
American journal of physiology. Heart and circulatory physiology  •  2003  |  View Paper
FK also enhanced the neuroprotective action of antioxidants that mimic the trophic effects of NA , such as trolox and pyrocatechol, but was totally ineffective by itself, suggesting that inhibition of oxidative stress was a required step to reveal the cAMP-dependent mechanism.
Molecular pharmacology  •  2002  |  View Paper
Antioxidant vitamins prevented the changes produced by NE.
Cardiovascular research  •  2001  |  View Paper