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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Norepinephrine
Research Papers that Mention the Interaction
“Carvedilol and several of its metabolites are potent antioxidants that may inhibit catecholamine toxicity resulting from the oxidation of norepinephrine and the subsequent formation of toxic intermediates, including the generation of reactive oxygen free radicals in the myocardium.”
Protective effects of carvedilol in the myocardium.“ Noradrenaline concentrations were associated with higher antioxidant concentrations.”
“Importantly, carvedilol and several of its metabolites are potent antioxidants that may inhibit the oxidation of norepinephrine and the subsequent formation of toxic intermediates, such as reactive free radicals in the myocardium.”
“The results obtained show that NE administration influences the antioxidant cellular defence system significantly increasing glutathione peroxidase (GPx) activity, glutathione reductase (GR) and superoxide dismutase (SOD).”
“ Antioxidant vitamins reduce cardiac oxidative stress and cardiomyocyte apoptosis produced by exogenous norepinephrine ( NE ) and attenuate cardiac dysfunction in animals with pacing-induced congestive heart failure (CHF).”
“FK also enhanced the neuroprotective action of antioxidants that mimic the trophic effects of NA , such as trolox and pyrocatechol, but was totally ineffective by itself, suggesting that inhibition of oxidative stress was a required step to reveal the cAMP-dependent mechanism.”
“ Antioxidant vitamins prevented the changes produced by NE.”
Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets.
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