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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Nitroprusside
Research Papers that Mention the Interaction
“However, SNP treatment increased the expression of genes involved in mitochondrial function and biogenesis, and elevated the anti-oxidant stress system and steroid synthesis.”
Effects of nitric oxide on steroidogenesis and apoptosis in goat luteinized granulosa cells.“This study indicates that SNP significantly affected the anti-oxidant system.”
“Based on the observed antioxidant activity of AKG, it may be suggested that the antioxidant mode of AKG action (apart from its cyanide-binding capability) may be used to prevent the toxic effects of SNP and improve general physiological state of D. melanogaster and other animals and humans.”
“ Antioxidants tiron and bilirubin prevented the loss of postictal cerebrovascular dilations to bradykinin, glutamate, and sodium nitroprusside.”
“Continuous perfusion … the antioxidants melatonin, trolox, 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrrimidinyl)-1-piperazinyl]-pregna-1,4,9(11)-triene-3,20-dione(Z)-2-butenedioate (U74389G), and diethyldithiocarbamate prevented the effect of sodium nitroprusside on MOR desensitization, but they did not themselves alter the desensitization.”
“Cell … SNP (100 micromolar), assessed either by an increased proportion of apoptotic nuclear morphology … mitochondrial complex II activity, was inhibited by a cocktail of known antioxidants (ascorbate, reduced glutathione, and dithiothreitol, all at 100 micromolar) but not by … at a concentration known to be neuroprotective in vivo (300 micromolar).”
“Conclusions A participation of oxidative stress was suggested during nitrate tolerance development, since antioxidants prevented the increase in lipid peroxidation and improved vascular responses to SNP and 5HT.”
“Supporting this conclusion, incubation of the DA standards with SNP caused a dose-dependent loss in DA levels, an effect that was reversed partially by oxyhemoglobin and inhibited completely by antioxidants.”
“Furthermore the antioxidant also strongly inhibited cell fusion, and its inhibitory effect was reversed by treatment with sodium nitroprusside , an NO-generating agent.”
“ Antioxidants and desferoxamine prevented both cytotoxicity and lipid peroxidation induced by SNP.”
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