Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure.

Platelet function in health and disease: from molecular mechanisms, redox considerations to novel therapeutic opportunities.

 may be a consequence of their enhancing or promoting the antiplatelet effects of 

 derived from both endothelial cells and platelets.

Antioxidants, lipoprotein oxidation, and arterial function

 and vasodilatation may be partially attenuated by 

Role of Nitric Oxide in Cardiovascular Adaptation to Intermittent Hypoxia

 synthesis and/or availability activates or increases expression of other protective factors, including heat shock proteins, 

 and prostaglandins, making the protection more robust and sustained.

The Nitric Oxide Theory of Aging Revisited

, such as melatonin, vitamin C, and vitamin E, probably play important roles in reducing or eliminating the oxidant damage produced by 

Antioxidant Improves Smooth Muscle Sarco/Endoplasmic Reticulum Ca2+-ATPase Function and Lowers Tyrosine Nitration in Hypercholesterolemia and Improves Nitric Oxide–Induced Relaxation

 reverses impaired smooth muscle SERCA function in HC, and this is correlated with the improved relaxation to 

Oxidative stress in endothelial cell dysfunction and thrombosis

 improve intracellular redox state and reverse ECD by improving the bioavailability of 

Pharmacological approaches to preserving and restoring coronary endothelial function

In addition, L-arginine, the substrate for NO synthesis, and the

 ascorbate and α-tocopherol, are able to increase 

 synthesis and bioavailability respectively.

alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release.

Excess vascular oxidative stress has been associated with impaired NO release, and

How does ascorbic acid prevent endothelial dysfunction?

The mechanism of the ascorbic acid effect is unknown, although it has been attributed to an

 of the vitamin to enhance the synthesis or prevent the breakdown of 

Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis.

 can be greatly amplified by the activation of signal transduction pathways that lead to the increased synthesis of endogenous antioxidants or down regulate responses to pro-inflammatory stimuli.

Modulation of expression of endothelial nitric oxide synthase by nordihydroguaiaretic acid, a phenolic antioxidant in cultured endothelial cells.

 may not only increase the bioactivity of 

 but also enhance expression of the eNOS enzyme.

On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction.

 present in the cells of the vascular wall decrease cellular production and release of reactive oxygen species (ROS), … endothelial activation (i.e., expression of adhesion molecules and monocyte chemoattractants), and improve the biologic activity of 

 (EDNO) through a cell- or tissue-specific antioxidant action.

The potential clinical impact of 20 years of nitric oxide research.

There are many classes of drugs with a rationale that may rely on enhancing the actions of

The nitric oxide hypothesis of aging

, such as melatonin, vitamin C, and vitamin E, probably play an important acute and chronic role in reducing or eliminating the oxidant damage produced by 

HLA-DR-mediated signals for hematopoiesis and induction of apoptosis involve but are not limited to a nitric oxide pathway.

 production was blocked by N(G)-monomethyl-L-arginine (NMMA), an inhibitor of NO synthase (NOS), and by the 

Diabetes mellitus, hypertension, and cardiovascular disease: which role for oxidative stress?

 release in experimentally induced diabetes may be prevented by a number of 

Antioxidant activities and mechanisms of polysaccharides

Secondly, by inhibiting the expression of iNOS mRNA and reducing

 production, it can significantly increase the 

 capacity and reduce oxidative stress injury.

Possible Artefacts of Antioxidant Assays Performed in the Presence of Nitroxides and Nitroxide-containing Nanoparticles.

As a result, supplementation of blood plasma with

 capacity of blood plasma assayed with ABTS•. Nitroxides oxidize Fe2+ and in this way interfere with the ferric-Xylenol Orange assay of peroxides.

These results point to the necessity of careful interpretation of

Telomere length and redox balance in master endurance runners: The role of nitric oxide

, preserving telomeres and contributing to the overall health of master athletesNO levels are inversely associated with biological age of master endurance runners

Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects.

CONCLUSIONS: The clinical and nutritional status as well as intake of nutrients with 

(Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of N

Antioxidants improve vascular function in children conceived by assisted reproductive technologies: A randomized double-blind placebo-controlled trial

 measured by ozone-based chemiluminescence (from 21.7 ± 7.9 to 26.9 ± 7.6 µM, p = 0.04) and FMD (from 7.… (from 33 ± 8 to 28 ± 6 mm Hg, p = 0.028) in ART children, whereas it had no detectable effect in control children.

A multilevel analytical approach for detection and visualization of intracellular NO production and nitrosation events using diaminofluoresceins.

 and/or reactive nitrosating species, it is also affected by the presence of 

The effect of oral L-arginine supplementation on fasting glucose, HbA1c, nitric oxide and total antioxidant status in diabetic patients with atherosclerotic peripheral arterial disease of lower extremities.

Tetrahydrobiopterin attenuates superoxide-induced reduction in nitric oxide.

, N-acetyl-L-cysteine, substantially attenuated the reduction in both BH4 and 

A multifaceted approach to maximize erectile function and vascular health.

Dietary phenolic acids and ascorbic acid: Influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids.

In the presence of lipids, the impact of each

 on nitrosation was inversely correlated with the levels of 

 they generated (R(2) = 0.95, p<0.01): gallic, chlorogenic, and ascorbic acid promoted nitrosation, whereas ferulic and caffeic acids markedly inhibited nitrosation.

Bench-to-bedside review: Nitric oxide in critical illness – update 2008

, can inhibit leukocyte adhesion, and can participate in antimicrobial defense, but can also have deleterious effects, including inhibition of enzyme function, promotion of DNA damage, and activation of inflammatory processes.

Hyperbaric oxygen, oxidative stress, NO bioavailability and ulcer oxygenation in diabetic patients.

Role of oxidative stress in hearing impairment in patients with type two diabetes mellitus.

 may have a protective effect on hearing, as may some 

[Effect of ethanol on metabolic syndrome].

Endothelial nitric oxide synthase requires the presence of

 in the reaction with peroxide anions and the accumulation of peroxynitrates.

Biphasic effect of IL-1beta on the activity of argininosuccinate synthetase in Caco-2 cells. Involvement of nitric oxide production.

, the stimulatory effect of IL-1beta on ASS activity was restored, as measured at 24 h. Finally, such an inhibiting effect of NO on ASS activity may be related, at least in part, to S-nitrosylation of the protein.

Impairment of plasma nitric oxide availability in senescent healthy individuals: apparent involvement of extracellular superoxide dismutase activity.

Findings of the present study suggest that the decrease of

 defence strategies play a primary role by compromising 

 availability in normally aged individuals, particularly through a progressive decrease of EC-SOD activity.

Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells.

 were involved in the modulation of toxic responses of 

Dietary habits and nutritional biomarkers in Italian type 1 diabetes families: evidence of unhealthy diet and combined-vitamin-deficient intakes

The combination of vitamin B9 and vitamin E deprivation could be deleterious for endothelial function, since these

 have been implicated in the modulation of 

Effect of change in cellular GSH levels on mitochondrial damage and cell viability loss due to mitomycin c in small cell lung cancer cells.

, including N-acetylcysteine, depressed formations of 

, malondialdehyde and carbonyls due to MMC in SCLC cells.

Antioxidant enzymes and pulmonary function in steel mill welders.

 and ozone lead to disturbances of the balance between oxidants and 

The postprandial effects of dietary antioxidants in humans

 have been shown to reduce oxidative modification to LDL cholesterol, prevent glucose auto-oxidation, improve the bioactivity of 

, and attenuate or prevent the decrease in endothelial function associated with the postprandial state.

Protective role of oral antioxidant supplementation in ocular surface of diabetic patients

, such as vitamin C and vitamin E, probably have an important role in reducing the oxidative damage produced by 

 and other free radicals and improving the ocular surface milieu.

The Alleviative Effects of Quercetin on Cadmium-Induced Necroptosis via Inhibition ROS/iNOS/NF-κB Pathway in the Chicken Brain

Cd exposure obviously increased Cd accumulation, ROS …, and MDA level; weakened the activities of

 (SOD, GPx, and CAT); … iNOS activity and 

 production; promoted the expression of inflammatory factors (NF-κB, TNFα, COX-2, iNOS, PTGEs, and IL-1β); and activated HSPs (HSP27, HSP40, HSP60, HSP70, and HSP90).

Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

Moreover, FL also elevated the amounts of

 enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach.

Dimethyl fumarate ameliorates acetaminophen‐induced hepatic injury in mice dependent of Nrf‐2/HO‐1 pathway

Evaluation of the renoprotective effect of nano turmeric against toxic dose of copper sulfate: Role of vascular cell adhesion molecule‐1, kidney injury molecule‐1, and signal transducer and activator of transcription 3 protein expressions

 downregulated the marked increase in urea, creatinine, uric acid, CRP, caspase‐3, 

, MDA, VCAM‐1, kidney injury molecule (KIM‐1), STAT‐3, NF‐κB, and DNA fragmentation, and increased Bcl‐2, IL‐10, GSH, and SOD levels induced by CS.

Neuroprotective mechanisms of sildenafil and selenium in PTZ‐kindling model: Implications in epilepsy

 as selenium‐the important element for TrxR activity‐will further activate VEGF at the expenses of nitrative stress and lipid peroxidation.

Dietary antioxidants prevent alcohol-induced ciliary dysfunction.

Kaempferol inhibits P. intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: critical role of heme oxygenase-1-mediated ROS reduction.

 downregulated the production of LPS-induced 

The antioxidant tempol decreases acute pulmonary thromboembolism-induced hemolysis and nitric oxide consumption.

 could attenuate APT-induced hemolysis, and therefore attenuate APT-induced increases in plasma 

Nitroglycerin prevents coagulopathies and foetal death associated with abnormal maternal inflammation in rats.

 (NO) functions as an inhibitor of platelet aggregation and 

, we also tested whether the NO mimetic nitroglycerin (glyceryl trinitrate, GTN) prevents inflammation-associated coagulopathies and foetal death.

Radical change for the fetus

Hence, during basal conditions, administration of

, such as vitamin C or melatonin, into the fetal circulation quenches ROS and increases 

Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin.

 or inhibitors of NADPH oxidase (glutathione, … diphenyleneiodonium chloride) to modulate nitric oxide (

) production and inducible nitric oxide synthase (iNOS) expression by mouse macrophages induced by lipopolysaccharide (LPS) … potential of apocynin to modulate the course of LPS-induced lung inflammation in vivo.

Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: therapeutic potential of arjunolic acid.

These results provide evidence that inhibition of

 overproduction and maintenance of intracellular 

 may play a pivotal role in the protective effects of AA against APAP-induced renal damage.

Inhibition of pro-inflammatory responses and antioxidant capacity of Mexican blackberry (Rubus spp.) extracts.

Melatonin and vitamin C increase umbilical blood flow via nitric oxide‐dependent mechanisms

Nitric oxide (NO) is important in the maintenance of umbilical blood flow, and

Nitric oxide-mediated protection of endothelial cells from hydrogen peroxide is mediated by intracellular zinc and glutathione.

 GSH by inducing the expression of the catalytic subunit of GCL (GCLC).

Carnitine deficiency aggravates carboplatin nephropathy through deterioration of energy status, oxidant/anti-oxidant balance, and inflammatory endocoids.

 balance and modulating the release of some inflammatory endocoids namely, TNF-alpha and 

 could also possibly account for such combinatorial detrimental toxicity.

Fiber Type-Specific Nitric Oxide Protects Oxidative Myofibers against Cachectic Stimuli

 gene expression and blocked cytokine/endotoxin-induced MAFbx/atrogin-1 expression in cultured myoblasts and in skeletal muscle in vivo.

The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.

 may play a pivotal role in the protective effects of alpha-LA against APAP-induced hepatic and renal damage.

Antioxidants combined with NO donor enhance systemic inflammation in acute lung injury in rats

 in combination should be avoided in clinical practice.

NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE KIDNEY AND THEIR IMPLICATION IN THE DEVELOPMENT OF SALT‐SENSITIVE HYPERTENSION

 has a major renoprotective effect against by acting as an 

[Effect of nitrogen oxide donor and inhibitor on some biochemical indices of the brain of intact rats and rats with subarachnoidal hemorrages].

It was established that an incubation of tissues with

 donator results in an increase of nitrits' level, some intensification of LPO and activation of 

Nox 2 stimulates muscle differentiation via NF-kappaB/iNOS pathway.

 restored muscle differentiation blocked by treatment with 

 or suppression of the Nox 2/NF-kappaB/iNOS pathway.

Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats.

Also our data suggest that antifibrotic affect of

 may be due to their inhibitory effect on 

Effects of various antioxidants on endotoxin-induced lung injury and gene expression: mRNA expressions of MnSOD, interleukin-1beta and iNOS.

 effectively reversed the systemic hypotension, reduced the quantity of exhaled 

 and plasma nitrate concentration, and prevented acute lung injury.

Perinatal L-Arginine and Antioxidant Supplements Reduce Adult Blood Pressure in Spontaneously Hypertensive Rats

 results in persistent reduction of SBP and renal protection in SHR, although effects on NOx and TBARS were only transient.

Effect of Vitamin C Supplementation on Oxidative DNA Damage in an Experimental Model of Lead-Induced Hypertension

Conclusions: These findings point to enhanced ROS-mediated inactivation and sequestration of

 which can potentially contribute to hypertension, lipid peroxidation, reduced 

ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel.

 triggering abolished protection, confirming that ROS are generated by K(ATP) channel activation.

Oxidation and Nitrosation in the Nitrogen Monoxide/Superoxide System*

, the PN actions are blocked, which may explain the 

 properties of⋅NO and the mechanism of cellularS-nitrosations.

Thiolic antioxidants protect from nitric oxide-induced toxicity in fetal midbrain cultures

Retinal glutamate in diabetes and effect of antioxidants

 inhibited the diabetes-induced increases in glutamate, TBARS and 

Effect of nitric oxide and plant antioxidants on microsomal content of lipid radicals.

 inhibit lipid peroxidation by a mechanism that has both common and non-shared features.

Effects of apocynin and natural antioxidant from spinach on inducible nitric oxide synthase and cyclooxygenase-2 induction in lipopolysaccharide-induced hepatic injury in rat.

Interpretation of the results of the immunostained tissues indicated that pretreatment with either

 significantly (P<0.05) attenuated the lipopolysaccharide-stimulated inducible 

Nitric Oxide Can Differentially Modulate Striatal Neurotransmitter Concentrations via Soluble Guanylate Cyclase and Peroxynitrite Formation

 to stimulate cyclic GMP formation during ageing, or neurodegenerative pathologies, may particularly impact on the functional consequences of NO on striatal dopaminergic and glutamatergic function.

Recovery by ascorbate of impaired nitric oxide‐dependent relaxation resulting from oxidant stress in rat aorta

This action is seen with ascorbate at levels normally present in plasma, suggesting that this

Tempicol-2 (4-hydroxy-4-(2-picolyl)-2,2,6,6-tetramethylpiperidine-1-oxyl), a stable free radical, is a novel member of nitroxide class of antioxidants and anticancer agents.

Yoshida Sarcoma, thus indicating that anticancer activity of the investigated

Differential induction of apoptosis in Swiss 3T3 cells by nitric oxide and the nitrosonium cation.

 was reduced in the presence of the NO scavenger oxyhaemoglobin, or the 

 N-acetylcysteine and ascorbic acid, whereas in the case of NO+ these antioxidants potentiated apoptosis.

Induction of NO synthesis in macrophages by Newcastle disease virus is associated with activation of nuclear factor-kappa B.

 synthesis and NF-kappa B activation were blocked by an 

 (butylated hydroxyanisole), by an inhibitor of protein tyrosine kinase (genistein) and of protein kinase A (H-89), but not by an inhibitor of protein kinase C (staurosporin).

Role of antioxidants in the nitric oxide-elicited inhibition of dopamine uptake in cultured mesencephalic neurons. Insights into potential mechanisms of nitric oxide-mediated neurotoxicity

Since the formation of NO as well as neurotransmitter release are activated during ischemia reperfusion injury, it is possible that prolonged

 and facilitate the oxidation of dopamine and thereby cause neurotoxicity.

Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages.

 was suppressed by protease inhibitor and 

, both of which block the activation of NF-kappa B. Surprisingly, the use of an NO synthase inhibitor resulted in an enhancement of NF-kappa B activation.

Antioxidants vs lung disease.

Crosstalk between abscisic acid and nitric oxide under heat stress: exploring new vantage points.

In the present review, the focus is shifted on the role of … molecules under heat stress emphasizing the different possible interactions between ABA and

 as both regulate stomatal closure and other … including hydrogen peroxide (H2O2), hydrogen sulfide (H2S), 

, proline, glycine betaine, calcium (Ca2+) … heat shock protein (HSP).

Effects of NO modulators and antioxidants on endocrine and cellular markers in rats under repetitive restraint stress

 differentially influence repetitive stress-induced changes in endocrine and cellular markers, and the complex interaction between NO and cellular markers like HSP70 and NF-κB plays a crucial modulatory role in this phenomenon.

Exogenous Nitric Oxide Reinforces Photosynthetic Efficiency, Osmolyte, Mineral Uptake, Antioxidant, Expression of Stress-Responsive Genes and Ameliorates the Effects of Salinity Stress in Wheat

 at both concentrations up-regulated the 

 for averting the NaCl-mediated oxidative damage on membranes.

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Possible Interaction: Antioxidants and Nitric Oxide

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Research Papers that Mention the Interaction