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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Nicotine
Research Papers that Mention the Interaction
“Nicotine stimulated podocyte ROS generation; nonetheless, antioxidants such as N-acetyl cysteine (NAC) and TEMPOL (superoxide dismutase mimetic agent) inhibited this effect of nicotine.”
Nicotine Induces Podocyte Apoptosis through Increasing Oxidative Stress“ Nicotine induces formation of oxygen radicals and at the same time also reduces the antioxidant capacity of the lungs.”
“ Nicotine induces formation of oxygen radicals and at the same time also reduces the antioxidant capacity of the lungs.”
“Additionally, in multivariate analyses, hair nicotine level was significantly negatively correlated with total antioxidant capacity.”
“Previously, we found that nicotine up-regulates peroxiredoxin 1 (Prx1), an important antioxidant enzyme, and nuclear factor kappa B (NFκB) in OSCC cells.”
“Moreover, it also exhibited potent antioxidant activities by diminishing the ROS and NO in the nicotine stimulated lymphocytes up to 200 μg/ml.”
“The results indicated that exposure to pesticides and nicotine can influence antioxidant enzymes activity.”
“The aim of this study is to address the hypothesis that nicotine impairs wound healing by increasing reactive oxygen species and inhibiting cell migration, and antioxidants (AOs) may counteract nicotine effects.”
“In addition, we investigated the mechanism by which nicotine induced antioxidant defense enzyme expression as a protective response.”
“ Nicotine induced the synthesis of the transcription factor NF-E2-related factor-2 (Nrf2) as well as a number of cellular antioxidants and phase II enzymes, such as heme oxygenase-1.”
“Pretreatment with antioxidants inhibited the upregulation of RANKL, the downregulation of OPG expression, and cytotoxicity by nicotine in PDL cells.”
“From our findings it is evident that nicotine absorption might contribute to the disturbed oxidant and antioxidant balance leading to oxidative stress.”
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