Possible Interaction: Antioxidants and Niacin

“The protective increase in HDL2 with simvastatin plus niacin was attenuated by concurrent therapy with antioxidants.”

“In conclusion, niacin especially at 800 mg/kg diet improves serum testosterone levels and antioxidant status of testes in normal rats.”

“A large number of studies have shown that nicotinamide can play an important role in infection and sepsis by repairing mitochondrial function to restore adenosine triphosphate (ATP) level, inhibiting poly (ADP-ribose) polymerase (PARP) activation, inhibiting proinflammatory mediators and antioxidant damage.”

“The addition of an antioxidant “cocktail,” comprising vitamins E and C, β-carotene, and selenium, for participants on simvastatin and niacin (SNA) therapy, resulted in a significant blunting of the apoA1 and HDL2c response compared with those on lipid-lowering drugs alone (SN).”

“In conclusion, a combination of NAM and BA can improve the performance, antioxidant capacity , mitochondrial function and intestinal microbiota of broilers at high stocking density.”

“Furthermore, Niacin reduces peroxynitite formation and improves antioxidant GSH.”

“Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione.”

“We found that NAM treatment decreased total oxidant status (TOS), caspase 3 (CASP3) and cytochrome c (CYC) levels and increased total antioxidant status (TAS), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels (P<0.05).”

“In summary, nicotinamide boosted the immune system through stimulation of adaptive immune cells with enhancement of antioxidant defences and reduced production of ROS.”

“From experiments in vitro (E. coli bacteria AB 1157) it was established that the cytostatic activity of nicotinamide (vitamin B3) in aqueous, aerated media (pH = 7.4) under irradiation with gamma-rays can be strongly enhanced in the presence of antioxidant vitamins.”