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Last Updated: 2 years ago

Possible Interaction: Antioxidants and Ng-Nitroarginine Methyl Ester

Research Papers that Mention the Interaction

Very interestingly, while acute treatment with L-NAME … ROS formation, chronic NO deprivation by long term L-NAME exposure drastically reduced … rise to an antioxidant environment characterized by an increase in superoxide dismutase-2 (SOD-2) expression … nuclear accumulation of the transcription factor NF-E2-related factor-2 (Nrf2).
Cellular signalling  •  2013  |  View Paper
Also N-nitro-l-arginine methyl ester (NAME), a competitive inhibitor of NOS, and combined incubation with NAME and antioxidant enzymes failed to attenuate MPP(+) cytotoxicity.
Experimental Neurology  •  2000  |  View Paper
Moreover, topical application of L-NAME significantly alleviated the lens nitrite, opacity, antioxidants (GSH, CAT, SOD, and GPx), MDA, proteins, and ionic (Na+ and Ca2+) contents.
Current eye research  •  2018  |  View Paper
Data suggest that argininic acid alters antioxidant defenses in the blood and kidney of rats; however, in the presence of antioxidants and L-NAME , most of these alterations in oxidative stress were prevented.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie  •  2017  |  View Paper
Treatment … NG-nitro-L-arginine methyl ester (L-NAME), a nitric … synthase (NOS) inhibitor, increased anti-oxidant biomarkers such as thetotal antioxidant capacity (T-AOC) and theactivities of catalase (CAT) and superoxide dismutase (…) but decreased a marker of peroxynitrite (ONOO-) action and 3-nitrotyrosine (3-NT) in endotoxemic lung.
Cellular Physiology and Biochemistry  •  2016  |  View Paper
The treatments with apocynin, indomethacin and L-NAME reduced the gene expression of antioxidant and oxidant enzymes.
Toxicology letters  •  2011  |  View Paper
Nitric oxide synthase (NOS) inhibitor, L-NAME was found to mitigate TAS levels in the blood serum of rats pretreated with NDEA and NMU.
Roczniki Panstwowego Zakladu Higieny  •  2005  |  View Paper
Inhibition of nitric oxide production by L-NAME improved end-systolic elastance to 84% +/- 12%,** limited conjugated diene elution (0.8 +/- 0.1 vs 1.3 +/- 0.2, no treatment**), and improved antioxidant reserve capacity (679 +/- 69 vs 910 +/- 59, no treatment**).
The Journal of thoracic and cardiovascular surgery  •  1995  |  View Paper