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“Very interestingly, while acute treatment with L-NAME … ROS formation, chronic NO deprivation by long term L-NAME exposure drastically reduced … rise to an antioxidant environment characterized by an increase in superoxide dismutase-2 (SOD-2) expression … nuclear accumulation of the transcription factor NF-E2-related factor-2 (Nrf2).”
“Also N-nitro-l-arginine methyl ester (NAME), a competitive inhibitor of NOS, and combined incubation with NAME and antioxidant enzymes failed to attenuate MPP(+) cytotoxicity.”
“Moreover, topical application of L-NAME significantly alleviated the lens nitrite, opacity, antioxidants (GSH, CAT, SOD, and GPx), MDA, proteins, and ionic (Na+ and Ca2+) contents.”
“Data suggest that argininic acid alters antioxidant defenses in the blood and kidney of rats; however, in the presence of antioxidants and L-NAME , most of these alterations in oxidative stress were prevented.”
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie • 2017 | View Paper
“Treatment … NG-nitro-L-arginine methyl ester (L-NAME), a nitric … synthase (NOS) inhibitor, increased anti-oxidant biomarkers such as thetotal antioxidant capacity (T-AOC) and theactivities of catalase (CAT) and superoxide dismutase (…) but decreased a marker of peroxynitrite (ONOO-) action and 3-nitrotyrosine (3-NT) in endotoxemic lung.”
Roczniki Panstwowego Zakladu Higieny • 2005 | View Paper
“Inhibition of nitric oxide production by L-NAME improved end-systolic elastance to 84% +/- 12%,** limited conjugated diene elution (0.8 +/- 0.1 vs 1.3 +/- 0.2, no treatment**), and improved antioxidant reserve capacity (679 +/- 69 vs 910 +/- 59, no treatment**).”