Possible Interaction: Antioxidants and Naringenin

“In placenta and visceral adipose tissue (VAT), naringenin significantly reduced expression of pro-inflammatory cytokines and chemokines and increased antioxidant mRNA expression.”

“ Naringenin treatment altered the biochemical and antioxidant parameters related to inflammation necessary for anticancer activity.”

“ Naringenin has been shown to exert antiestrogenic, cholesterol-lowering and antioxidant activities , as well as an indirect modulation on the metabolism of many xenobiotics.”

“ NG also significantly raised the decreased testicular Bcl-2/Bax ratio, and total antioxidant status in CP- and DX-challenged rats.”

“Further, naringenin inhibited alkali-induced cytokine (IL-1β and IL-6) production, Vegf, Pdgf, and Mmp14 mRNA expression, and the reduction of ferric reducing antioxidant power and Azinobis-(3-Ethylbenzothiazoline 6-Sulfonic acid) radical scavenging capacity as well as increased the reduced glutathione and protein-bound sulfhydryl groups levels.”

“ Naringenin pretreatment also increased the antioxidant status of irradiated mice.”

“These changes in antioxidant enzymes and successive lipid peroxidation were prevented by NAR supplementation, resulting in decreases in the risk of toxicity due to DOX therapy.”

“ Naringenin exerts antioxidant and anti-inflammatory effects.”

“In addition, NGN inhibited the production of NO and trigged the synthesis of antioxidant marker enzymes.”

“Coadministration of NGEN to iron-treated rats significantly improved antioxidant enzyme activities and attenuated oxidative damages observed in the cerebral cortex.”