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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Morphine
Research Papers that Mention the Interaction
“Because proliferative and proapoptotic effects of morphine were inhibited by free radical scavengers as well as antioxidants , it appears that these effects of morphine are mediated through oxidative stress.”
Role of oxidative stress and heme oxygenase activity in morphine-induced glomerular epithelial cell growth.“The deleterious actions of morphine can be countered by antioxidant system.”
“However, … morphine consumption within the first 48 h was smaller in the treatment groups (0.22 ± 0.… mg kg−1 and 0.22 ± 0.23 mg kg−1 in the preconditioning and antioxidant groups , respectively) than in the control group (0.47 ± ….33 mg kg−1, P <0.05).”
“Furthermore, morphine exposure resulted in upregulation of the antioxidant enzyme catalase.”
“ Morphine was able to increase total antioxidant capacity of H9c2 cells and to reduce the production of reactive oxygen species, protein carbonylation, and lipid peroxidation.”
Protective Effect of Morphine Against the Oxidant-Induced Injury in H9c2 Cells“Pretreatment with an antioxidant H-290/51 markedly attenuated the BBB dysfunction, brain edema formation and brain pathology during morphine withdrawal phases.”
“It was … that morphine administration (30 mg/kg of body weight) caused an increase of the amount of thiobarbituric acid reactive substances (TBARS), alteration of antioxidant enzymes activity, decrease the protein level, quantity of total lipids and phospholipids, phosphatidylcholine, cholesterol esters; altered the content of some individual fatty acids.”
“The present study was designed to determine whether an antioxidant could inhibit SIB or mortality directly induced by methamphetamine and/or morphine.”
“CONCLUSIONS Mo phine in creased the ipsilateral intratesticular ant ioxidant ma rkers during the reperfusion phase after unilateral testicular torsion, which was eventually reflected in lower testicular malondialdehyde levels.”
“These results implied that morphine caused a seriously oxidative stress in mice livers and hence caused hepatotoxicity, while exogenous antioxidants were able to prevent the oxidative damage of biomolecules and hepatotoxicity caused by morphine.”
“Several studies have suggested opioid antagonist and antioxidant therapy for reducing adverse effects of morphine.”
Behavioral, histopathological, and biochemical evaluations on the effects of cinnamaldehyde, naloxone, and their combination in morphine-induced cerebellar toxicity.
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