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Possible Interaction: Antioxidants and Methotrexate

supplement:

Antioxidants

Research Papers that Mention the Interaction

MTX use has been linked to oxidative imbalance, which may cause multi-organ toxicities that can be attenuated by antioxidant supplementation.
PloS one  •  2014  |  View Paper
Oncologists at an influential oncology institution contended that antioxidants interfere with radiation and some chemotherapies because those modalities kill by generating free radicals that are neutralized by antioxidants, and that folic acid interferes with methotrexate.
Alternative therapies in health and medicine  •  2007  |  View Paper
Oncologists at an influential oncology institution contended that antioxidants interfere with radiation and some chemotherapies because those modalities kill by generating free radicals that are neutralized by antioxidants, and that folic acid interferes with methotrexate.
Alternative therapies in health and medicine  •  2007  |  View Paper
The net results appear to show that the biological situation resulting from treatment with MTX leads to a reduction of effectiveness of the antioxidant enzyme defence system.
Cell biochemistry and function  •  1998  |  View Paper
Furthermore, MTX caused a significant decrease in the activities of hepatic enzymic antioxidants (superoxide dismutase, catalase, glutathione S-transferase) and nonenzymic antioxidants (Vitamin C and glutathione), followed by a significant increase in hepatic malondialdehyde content.
Journal of xenobiotics  •  2016  |  View Paper
Use of antioxidants such as CAR may protect germ cells against oxidative stress and apoptosis when used in combination with MTX.
International journal of clinical and experimental medicine  •  2014  |  View Paper
Taken together, antioxidants such as APC when combined with MTX not only potentiated the antiarthritic effect but importantly alleviated the MTX-induced hepatic damage, thus endorsing its effectiveness in preventing progression of articular diseases such as rheumatoid arthritis.
Free radical research  •  2018  |  View Paper
MTX … antioxidants in liver tissues [control group: 3.02 (2.85-3.43) μmol/g and 71.78 (61.88-97.81) U/g vs model ….62) μmol/g and 69.22 (61.13-100.88) U/g, P < 0.05 and P < 0.01 vs model group respectively].
MTX … antioxidants in liver tissues [control group: 3.02 (2.85-3.43) μmol/g and 71.78 (61.88-97.81) U/g vs model ….62) μmol/g and 69.22 (61.13-100.88) U/g, P < 0.05 and P < 0.01 vs model group respectively].
World journal of gastroenterology  •  2014  |  View Paper
Use of these antioxidants , in combination with chemotherapeutics, may help to reduce some adverse effects of methotrexate.
Clinical and investigative medicine. Medecine clinique et experimentale  •  2014  |  View Paper
BACKGROUND Studies related to the use of various antioxidant and anti-inflammatory drugs to decrease the toxic side effects related to MTX have been carried out.
European review for medical and pharmacological sciences  •  2013  |  View Paper
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