Possible Interaction: Antioxidants and Methacholine

“Airway responsiveness to methacholine was also increased by vitamin E depletion and decreased slightly by supplementation with the antioxidant.”

“The ileal inhibitory effects of these antioxidants became more pronounced with successive concentration-responses in the presence of methacholine but not with duration of exposure in the absence of methacholine, suggesting depletion of cellular energy stores by the antioxidants with successive ileal contractions.”