Possible Interaction: Antioxidants and Metformin

“The administration of antioxidants such as melatonin and zinc may improve tissue responses to insulin and increase the efficacy of drugs, e.g. metformin , which act through this pathway.”

“On the other hand, metformin could significantly enhance the total antioxidant capacity in BPA rats.”

“Disrupting the antioxidant HO-1 activity, especially under low glucose concentration, could be an attractive approach to potentiate metformin antineoplastic effects and could provide a biochemical basis for developing HO-1-targeting drugs against solid tumors.”

“Moreover, applying metformin as either a pretreatment or co-treatment could reduce the amount of reactive oxygen species, enhance antioxidant capacity, and rescue the cell viability and osteogenic differentiation that were negatively affected by H2O2-induced oxidative stress in PDLSCs.”

“ConclusionsOur data indicate that metformin may play a pivotal role in modulating the anti-oxidant system , including the SOD machinery, in breast cancer-derived cells.”

“Our results showed metformin induced oxidative stress and reduced antioxidant capacity.”

“Additionally, metformin increased the expression of the antioxidant thioredoxin (Trx), which mediated metformin's effects on ROS reduction.”

“ConclusionsWe conclude that initiation of metformin treatment in type 2 diabetic patients is associated with improved diabetes control as well as with activation of oxidative stress together with antioxidant system.”

“Our results showed that the exercised group treated with MTF for 12 months presented higher GSH/GSSG rate and high antioxidant scavenging power in contrast to the MTF-treatment for 6 months, where the beneficial effect was less noticeable.”

“Conclusion: Our findings showed that the combined use of high-dose aspirin, metformin , captopril and atorvastatin potentiated their antioxidant effects on the brain, and hence could potentially improve cognitive function with their neuroprotective effects on hippocampus.”