Possible Interaction: Antioxidants and Melatonin

“ Melatonin induced changes in oscillations of anti‐oxidant genes (Nrf2, HO‐1, and Keap1) subtly contributed in the overall improvement in NAFLD recorded herein.”

“The co-treatment with melatonin could alleviate these compliances through its anti-oxidant and anti-inflammatory actions.”

“A concentration-dependent increase in the expression of the antioxidant enzymes catalytic subunit of glutamate-cysteine ligase, catalase, NAD(P)H-quinone oxidoreductase 1 and heme oxygenase-1 was detected in cells incubated with melatonin.”

“ Melatonin also suppressed AA-induced oxidative stress, as evidenced by the downregulation of 4-hydroxynonenal and reduced level of malondialdehyde, and modulated expression of pro-oxidant and antioxidant enzymes.”

“Quercetin, melatonin , lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant , anti-apoptotic and/or anti-autophagic properties.”

“In addition, melatonin stimulates antioxidant enzymes and can prevent free radical formation.”

“In addition to their ability to scavenge several reactive oxygen and nitrogen species, melatonin increases the activity of the glutathione redox enzymes, that is, glutathione peroxidase and reductase, as well as other antioxidant enzymes.”

“ Melatonin also enhances the antioxidant potential of the cell by stimulating the synthesis of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase, and by augmenting glutathione levels.”

“Multiple evidences reveal that the rhythmicity of melatonin has a crucial role in a variety of cardiovascular pathophysiological processes including anti-inflammatory, antioxidant , anti-hypertensive and possibly as an antilipidemic function.”

“ Melatonin also enhances the antioxidant potential of the cell by stimulating the synthesis of antioxidant enzymes like superoxide dismutase, glutathione peroxidase and glutathione reductase, and by augmenting glutathione levels.”