Possible Interaction: Antioxidants and Masoprocol

“Both indomethacin and NDGA also showed significant anti-oxidant property.”

“In conclusion, we provide evidence that NDGA improves metabolic dysregulation by simultaneously modulating the PPARα transcription factor and key genes involved in fatty acid oxidation, key antioxidant and lipogenic enzymes, and apoptosis and ER stress signaling pathways.”

“The inhibitory effects of NDGA on calcium influx and cell proliferation each had a mean inhibitory dose of 2-3 microM. Although NDGA also effectively inhibits cyclooxygenase and lipoxygenase, the addition of prostaglandins or leukotrienes could not reverse this inhibition nor could it be replicated by other antioxidants.”

“The induction of alkaline labile lesions was partially inhibited in the presence of an antioxidant NDGA.”

“The antioxidant nordihydroguaiaretic acid at 100 microgram/ml delayed the growth and toxin production for the entire incubation period (7 days).”

“… antioxidant nordihydroguaiaretic acid not only alleviates senescence of growth rate in each of the systems, but also alleviates or prevents the occurence of a number of … membranes and lipid peroxidation, excessive lipid peroxidation in plasma membranes during senescence appears to lead to abnormality of their osmotic and permeability properties.”