Possible Interaction: Antioxidants and Manganese

“Administration of an antioxidant , such as vitamin E, also partially prevented striatal dopamine decline induced by intranigral manganese infusion.”

“The interventions did not lead to decreased genomic marker despite a few cancer related studies, where particularly MN frequency in mucosa lesions and leukoplakia was reduced by green tea and antioxidants.”

“CONCLUSIONS: The clinical and nutritional status as well as intake of nutrients with ntioxidant properties (Cu, Zn, M n, vitamin C and ω3) appears to modulate the variation of NO in this population.”

“In conclusion, our results suggest that Mn play a crucial role in antioxidant capacity and we hypothesize that antioxidant defense is preserved in the cytosol (superoxide dismutase Cu/Zn -SOD), whereas it is impaired in mitochondria (Mn-SOD), which makes this cell organelle a true therapeutic target in diabetes.”

“When cells were treated with manganese for 24h, ROS dose-dependently increased while antioxidant intracellular GSH decreased.”

“… MN … antioxidants , including SOD (Point: 60th day, MN, HN v.s. CK: 258.36, 203.73 v.s. 326.95 U/mL), CAT (1.97, 1.….54, 9.73 v.s. 5.27 nmol/L), suggesting that NO3- exposure leading to a disruption of the redox status in fish.”

“Concentrations of Cu, Fe, Co, and Mn may play a role in regulating the antioxidant system components’ activity.”

“Furthermore, 20 and 30 mg/kg Mn and 5 × 109 CFU/kg BS significantly enhanced the total antioxidant capacity by increasing the activity of total superoxide dismutases or decreasing the content of malondialdehyde.”

“In conclusion, dietary inclusion of Mn and BS could improve the production performance, egg quality, antioxidant capacity , intestinal structure, as well as gut microbiota.”

“Al and Al + Mn produced different effects, and the timing of enzymatic and non-enzymatic antioxidant defenses also differed.”

“In this study, the acute sub‐lethal effects of manganese on blood antioxidant response, immune status and erythron profile were determined … (3.88 ± 0.193 mg/L and 7.52 ± 0.234 mg/L Mn2+) for 96 h. Significant increases in blood antioxidant enzyme activity like … exposed to manganese.”

“Our data shown also that manganese could trigger antioxidant response , modulate immune response and induce erythron profile modification leading to eryptosis, compromising the blood oxygen carrying capacity, and overall health status in fish.”