Possible Interaction: Antioxidants and Malathion

“ Malathion also produced lipoperoxidation, thiol (-SH) groups decrease as well as a significant-depletion (P < 0.05) of antioxidant enzyme activities such as catalase (CAT) and glutathione peroxidase (GPx), total superoxide dismutase (SOD), Cu/Zn-SOD and Mn-SOD in testis and epididymis.”

“In conclusion, this study demonstrated that malathion caused oxidative stress and negative alterations on the antioxidant enzyme activities of the fish.”

“However, the increase in antioxidant enzyme activities like superoxide dismutase and glutathione-S-transferase by malathion exposure suggested a hormetic response.”

“ Malathion exposure also resulted in increased DNA fragmentation and decline in both antioxidant enzymes activity namely catalase (CAT) and superoxide dismutase (SOD) in granulosa cells of antral follicles.”

“In conclusion, the findings of this study demonstrated that malathion caused oxidative stress and negative alterations on the antioxidant enzyme activities of the fish.”

“The findings of this study demonstrate that malathion has a negative effect on the haematological parameters, immune response, and antioxidant enzyme activities of the fish.”

“Besides AChE inhibition, malathion may act as a pro-oxidative agent by interfering with antioxidant defences , as shown by a decrease of glutathione peroxidase and glutathione reductase activity in the cerebral cortex (100 mg/kg malathion).”

“ Malathion at doses of 100 ppm, 500 ppm and 1500 ppm increased plasma antioxidant power by 33% (P<0.01), 59% (P<0.01) and 118% (P<0.01) of control, respectively.”

“Moreover, malathion exposure elevated the levels of lipid peroxidation followed by changes in antioxidant enzymes status.”

“These results demonstrate that malathion increases oxidative stress and decreases the antioxidant status while Res has a protective function against malathion toxicity in rats.”