Possible Interaction: Antioxidants and Lycopene

“Moreover, LYC treatment activated the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and downregulated inflammatory cytokines IL-1β and TNF-α in mice hippocampus.”

“These findings are supported by in vitro and in vivo experiments showing that lycopene not only enhances the antioxidant response of prostate cells, but that it is even able to inhibit proliferation, induce apoptosis and decrease the metastatic capacity of prostate cancer cells.”

“In conclusion, high intake of lycopene and reduced red meat consumption increase TAS.”

“Simultaneously, lycopene induces enzymes of the cellular antioxidant defense systems by activating the antioxidant response element transcription system.”

“This review focuses also on the synergistic effects of lycopene with other natural antioxidants that might be important for its future application in anti-cancer treatment.”

“We have previously reported a decreased incidence of leiomyomas in the oviduct of Japanese quail with antioxidant supplementation, for example, lycopene and soy isoflavones.”

“It is also clear that the form of lycopene used (purified versus food sources), dose of lycopene and concomitant use with other carotenoids and antioxidants , duration of exposure, specific target populations, and stage of disease appear to play a major role in determining agonistic or antagonistic effects.”

“Moreover, lycopene upregulated detoxification and antioxidant enzymes, probably via its regulatory effects on Air- and RF-dependent pathways.”

“ Lycopene upregulates Nrf2 levels in nuclear extracts and increases the transactivity of antioxidant response elements.”

“This study was undertaken to determine the cellular and molecular mechanisms by which the antioxidants β-carotene and lycopene inhibit AFB1-induced toxic changes in human hepatocytes (HepG2 cells).”

“We hypothesize that an effect of lycopene may be modified by XRCC1 genotype and other antioxidants.”