Possible Interaction: Antioxidants and Lutein

“Lutein treatment subsequently blocked the expression of intracellular cell survival proteins, phosphorylated …, phosphorylated extracellular‐regulated kinase 1/2, and nuclear factor‐kB. Suppression of antioxidant defense and … by lutein was further linked to apoptosis induction with elevated caspase‐3 … downregulated expression of Bcl‐2 and poly‐ADP ribose polymerase.”

“The literature indicates that antioxidant supplements plus lutein have a reasonable probability of retarding AMD.”

“Abstract Objective: To test the hypothesis that lutein , compared to the placebo, would enhance the total antioxidant status (TAS) in the preterm infants.”

“We tested the hypothesis that lutein would act both by increasing antioxidant capacity and inhibiting OS.”

“Statistically significant increases in MPOD density were observed in the lutein group for patients with baseline MPOD <or=0.3 optical density units and up to 0.2 optical density units in the lutein plus antioxidant group.”

“Also, LU significantly improved (p < 0.01) the antioxidants [catalase (CAT), superoxide dismutase (SOD)] as well as markedly upregulated (p < 0.01) the protein expression of HO-1 and Nrf2.”

“Pretreatment with lutein significantly increased the total antioxidant capacity with a concomitant decline in the total oxidant status.”

“These results demonstrated clear evidence that lutein offered a significant protective effect against I/R injury by enhancing antioxidant defense mechanisms.”

“Data suggested that xanthophyll supplementation enhanced antioxidant capacity and reduced lipid peroxidation in different tissues of hens and chicks.”

“Other lipid-soluble antioxidants lutein and vitamin E) may also improve the plasma antioxidant capacity.”

“Serum concentrations of lutein at follow-up, presumably reflecting recent intake of antioxidant supplements , raised MPOD levels significantly at 1.0° and 2.0° (both p < 0.01) but not in the central fovea.”