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“Concomitantly, lupeol pre-treatment for 24h significantly increased the levels of anti-oxidant enzymes , superoxide dismutase (SOD) and catalase and decreased ROS generation and LPO.”
“Furthermore, lupeol enhanced the mitochondrial antioxidant and redox status and inhibited DNA damage and cell death by preventing the downregulation of Bcl-2, upregulation of Bax, release of cytochrome c and the activation of caspase 9/3.”