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Last Updated: 2 years ago

Possible Interaction: Antioxidants and Levodopa

supplement:

Antioxidants

Research Papers that Mention the Interaction

The time when levodopa became necessary was extended by 2.5 y in the group taking antioxidants.
The American journal of clinical nutrition  •  1991  |  View Paper
Concomitant use of potent anti-oxidants along with L-DOPA would help in attenuating the neurodegeneration caused by endogenous 6-OHDA and would ultimately delay the progression of PD.
Medical hypotheses  •  2012  |  View Paper
Such toxic effects of levodopa can be blocked by co‐treatment with antioxidants , particularly thiol‐containing compounds.
Annals of neurology  •  1998  |  View Paper
Levodopa‐induced apoptosis was inhibited by antioxidants , indicating that it may be mediated by autooxidation‐reactive species.
Movement disorders : official journal of the Movement Disorder Society  •  1997  |  View Paper
However, the combination of each antioxidant with L-DOPA was effective at preserving cell viability.
Neuroreport  •  2012  |  View Paper
We investigated whether homocysteine (Hcy)‐ lowering therapy or an antioxidant prevented bone loss in Parkinson's disease (PD) patients taking levodopa.
Movement disorders : official journal of the Movement Disorder Society  •  2010  |  View Paper
This hypothesis suggests that antioxidant therapies may slow the rate of progression of PD and raises concern that metabolites of levodopa therapy may accelerate the rate of neuronal degeneration.
Neurology  •  1990  |  View Paper
Combining the L-dopa therapy with antioxidants can reduce related sideeffects and provide symptomatic relief.
Regulatory toxicology and pharmacology : RTP  •  2016  |  View Paper
The present study provides novel information on L-DOPA-induced neurotoxicity and suggests the concomitant use of an antioxidant with L-DOPA in order to enhance the life span of L-DOPA therapy.
Brain Research  •  2005  |  View Paper
The selective toxic effect of L-DOPA on rotenone-pretreated DA neurons was significantly blocked by antioxidants , but not antagonists of NMDA or non-NMDA glutamate receptors.
Brain Research  •  1997  |  View Paper
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