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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Levodopa
Research Papers that Mention the Interaction
“The time when levodopa became necessary was extended by 2.5 y in the group taking antioxidants.”
An open trial of high-dosage antioxidants in early Parkinson's disease.“Concomitant use of potent anti-oxidants along with L-DOPA would help in attenuating the neurodegeneration caused by endogenous 6-OHDA and would ultimately delay the progression of PD.”
“Such toxic effects of levodopa can be blocked by co‐treatment with antioxidants , particularly thiol‐containing compounds.”
“ Levodopa‐induced apoptosis was inhibited by antioxidants , indicating that it may be mediated by autooxidation‐reactive species.”
“However, the combination of each antioxidant with L-DOPA was effective at preserving cell viability.”
“We investigated whether homocysteine (Hcy)‐ lowering therapy or an antioxidant prevented bone loss in Parkinson's disease (PD) patients taking levodopa.”
“This hypothesis suggests that antioxidant therapies may slow the rate of progression of PD and raises concern that metabolites of levodopa therapy may accelerate the rate of neuronal degeneration.”
“Combining the L-dopa therapy with antioxidants can reduce related sideeffects and provide symptomatic relief.”
Protective effect of two essential oils isolated from Rosa damascena Mill. and Lavandula angustifolia Mill, and two classic antioxidants against L-dopa oxidative toxicity induced in healthy mice.“The present study provides novel information on L-DOPA-induced neurotoxicity and suggests the concomitant use of an antioxidant with L-DOPA in order to enhance the life span of L-DOPA therapy.”
“The selective toxic effect of L-DOPA on rotenone-pretreated DA neurons was significantly blocked by antioxidants , but not antagonists of NMDA or non-NMDA glutamate receptors.”
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