Possible Interaction: Antioxidants and Levocarnitine

“The application of physiological (…-physiological (1mM) doses of L-carnitine causes a significant decrease of the specific activity of nitric oxide synthase (NOS, 2.25+/-0.… pmol/(minmg)+/-0.09 pmol/(minmg) at 0.1mM), proliferation and a tendentious decrease of the antioxidant defence potential against … in control cells.”

“Above all, LC reduced ROS production and simultaneously increased protein content of antioxidant factors , SOD2 and Nrf2.”

“Endogenous anti-oxidant defense components including total anti-oxidative capacity, glutathione peroxidase, catalase, and superoxide dismutase were also promoted by L-carnitine.”

“The antioxidant enzyme activities of new born and weaning piglets were increased (P<0.05) by maternal dietary l-carnitine but this did not extend to finishing pigs.”

“ L-carnitine decreased malondialdehyde, glucose, insulin, HbA1c and MuRF1 and increased ISI and antioxidants.”

“In conclusion, l-carnitine promotes GCO cell growth and improves antioxidant function , it plays a protective role against oxidative stress induced by H2O2 in GCO cells, and the appropriate supplemental amount of l-carnitine is 0.1–1 mM.”

“Similar to this, L-carnitine may play a major role in the stability of the antioxidant status in the kidney, liver, spleen and lung of the CIN rat model.”

“Moreover, increased brain Na+,K+-ATPase activity could be a marker of T deficiency in WE, while combined T and antioxidant co-supplementation of Cys and/or Carn could be neuroprotective in terms of restoring the examined crucial brain enzyme activities to control levels.”

“Supplementation with vitamins A, C, and E, L-carnitine , and α-lipoic acid significantly increased the antioxidant capacity of inner ear tissues.”

“Both l-carnitine and captopril augmented the antioxidant defense capacity in SHRs.”