Possible Interaction: Antioxidants and Kaempferol

“ KFL upregulated Nrf2 phosphorylation and the expression of antioxidant genes HO-1 and NQO-1 in a dose-dependent manner under ZEA-induced oxidative stress.”

“Deletion of the antioxidant response element in the human SESN2 promoter inhibited increased luciferase activation by luteolin , suggesting that Nrf2 is a critical transcription factor for luteolin-dependent SESN2 expression.”

“Moreover, kaempferol act as a scavenger of free radicals and superoxide radicals as well as preserve the activity of various anti-oxidant enzymes such as catalase, glutathione peroxidase, and glutathione-S-transferase.”

“They showed that luteolin increased the levels of proteins involved in cell death and antioxidant responses by causing DNA-modifying enzymes to strip suppressive chemical markers off the gene encoding Nrf2, a protein that regulates antioxidant effects.”

“ Kaempferol promoted antioxidant enzymes, inhibited ROS generation and lipid peroxidation and finally prevented the occurrence of hemolysis.”

“ Luteolin decreases interactions between Nrf2 and the antioxidant response element sites of its target anti‐apoptotic and antioxidant proteins, Bcl‐2, Bcl‐XL, and HO‐1, which results in decreased constitutive Nrf2 activation.”

“None of the substances showed a phototoxic effect, and only luteolin had a moderate photoprotective effect at 2 µg/mL. The combination of luteolin, … and a complete photoprotection at 2 µg/mL.In summary, our findings suggest that the potent antioxidant and photoprotective effect of flavonoids like luteolin … antioxidants ….”

“However, kaempferol activated nuclear factor-E2-related factor 2 (Nrf2)/SLC7A11/GPX4 signaling, augmented antioxidant capacity, and suppressed the accumulation of lipid peroxidation in OGD/R-treated neurons.”

“The results showed that LUT activated Nrf2 pathway and increased the antioxidant defense capacities of OTA treated cells.”

“ Luteolin increased survival rate and augmented antioxidant markers in flies.”