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Last Updated: 2 years ago

Possible Interaction: Antioxidants and Isoproterenol

Research Papers that Mention the Interaction

Administration of isoproterenol caused a significant decrease in endogenous antioxidants i.e., myocardial catalase, GSH and GPx activity, and mitochondrial enzyme activities like citrate synthase and β hydroxyacyl CoA dehydrogenase.
Nitric oxide : biology and chemistry  •  2012  |  View Paper
ISO administration induced significant reduction in endogenous antioxidant enzymes like reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and raised thiobarbituric acid reactive substances (TBARS) indicating activated lipid peroxidation.
Clinical and experimental hypertension  •  2019  |  View Paper
Also, ISO caused significant glutathione depletion, lipid peroxidation and reduction in activities of antioxidant catalase enzyme.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2018  |  View Paper
Therapeutic intervention with antioxidants has been shown useful in preventing the deleterious changes produced by ISP.
Indian journal of experimental biology  •  2015  |  View Paper
Isoproterenol also significantly (p < 0.05) decreased antioxidants , superoxide dismutase, catalase, glutathione peroxidase, glutathione and increased leakage of cardiac injury markers; creatine phosphokinase-MB isoenzyme, lactate dehydrogenase concomitant to increased lipid peroxidation and histopathological perturbations.
Acta poloniae pharmaceutica  •  2012  |  View Paper
Isoproterenol significantly increased the release of LDH, CK in serum, decreased the antioxidant status in the heart along with an increase in lipid peroxidation.
Molecular and Cellular Biochemistry  •  2012  |  View Paper
ISO significantly reduced antioxidants - CAT, GPx, and membrane bound enzymes - Na(+)/K(+), Ca(2+) and Mg(2+) ATPases.
Journal of ethnopharmacology  •  2012  |  View Paper
The results show increased LPO and altered antioxidant system in erythrocytes in response to isoproterenol induced oxidative stress.
Indian journal of physiology and pharmacology  •  2000  |  View Paper
The levels of antioxidants such as ceruloplasmin, glutathione and the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase decreased significantly in isoproterenol administered rats when compared to control.
Indian journal of physiology and pharmacology  •  1997  |  View Paper
Antioxidants may prevent the formation of oxidative metabolites from ISO and the subsequent calcium overload.
Biochemical pharmacology  •  1984  |  View Paper
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