Possible Interaction: Antioxidants and Isoflavones

“Studies in animal models and cultured vascular cells have established that isoflavones increase eNOS activity and expression and activate the Nrf2-Keap1 signaling pathway, leading to an upregulation of detoxifying and antioxidant defense genes.”

“Soy products and isoflavones intake have been shown to exert antioxidant effects.”

“BACKGROUND Animal studies have shown that soy protein and isoflavones can increase antioxidant capacity and improve insulin resistance, and thus ameliorate nonalcoholic fatty liver disease (NAFLD).”

“Therefore, these isoflavones can potentially act as an NO promoter and as an antioxidant.”

“Total intake of isoflavones exceeded that of other dietary antioxidants , such as flavonoids, carotenoids (3.5 mg/d) and vitamin E (8.2 mg/d), and was approximately one half of the vitamin C intake (109 mg/d).”

“Additionally, ASII treatment led to significant improvement in lens antioxidants (catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione) and decreased lens malondialdehyde, compared to the control group (group II).”

“CONCLUSION Soy is flavone ca n reduce the hepatic lipid deposition and increase ant ioxidant ca pacity, the mechanism may be related to inhibition of SREBP-1c and activation of PPARα expression in liver.”

“However, it is still unknown whether antioxidants and isoflavones have comparable inhibitory effects on the progression of advanced stages of atherosclerosis.”

“The results obtained provide experimental evidence that isoflavone supplementation confers protection against peroxidative damage to membrane lipids in vivo, possibly through enhancing the activities of the antioxidant enzymes catalase and SOD.”

“Dietary administration of the soybean isoflavone genistein (50 and 250 ppm) for 30 days significantly increases the activities of antioxidant enzymes in various organs of SENCAR mice.”