Possible Interaction: Antioxidants and Iron, Dietary

“ Antioxidant status was impaired after the Fe period, as indicated by decreased FRAP (P < 0.005) and delta-ALAD activity (P < 0.05) and increased EOF (P < 0.01).”

“LY221068, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxy phenyl]methylene]-3-(dimethylamino)-4-thiazolidinone, and the monomethylamino analog, LY269415, are anti-oxidants and potent inhibitors of iron dependent lipid peroxidation and 5-lipoxygenase enzyme.”

“Significantly lower concentrations of iron were found in controls and in those receiving combined iron and antioxidant treatment (vitamin E + selenium) than in iron-only treated mice.”

“The reactivation of latent HIV-1 by iron or heme arginate was inhibited by antioxidant N-acetyl cysteine, or by an iron chelator desferrioxamine, suggesting that the effects were mediated by iron- or heme-induced redox stress.”

“In contrary, iron induces a greater decrease in antioxidant , compatible with higher oxidative stress in volunteers than in critically ill patients.”

“Among the metal ions examined, only iron and copper generated ROS in the presence of antioxidants.”

“After treatment with antioxidants , the expressions of ROS, Caspase-3 and apoptosis of iron overloading IRP BMMNC significantly decreased, but opposite for Bcl-2.”

“After one month supplementation of antioxidants , catalase was elevated significantly (P < 0.001) and marginal rise in serum TIBC concentration increased marginally while iron and ferritin were decreased marginally (P > 0.05) when compared with controls and baselines values.”

“In the presence of a biological reductant antioxidant ), redox cycling of iron could disrupt the redox balance within the cellular milieu.”

“ Iron was shown to reduce in situ 26S proteasome activity in SH-SY5Y cells and the reduction was protected by antioxidants.”