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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Insulin
Research Papers that Mention the Interaction
“The administration of antioxidants such as melatonin and zinc may improve tissue responses to insulin and increase the efficacy of drugs, e.g. metformin, which act through this pathway.”
Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin“It also had the effects of antioxidation which improved the sensitivity to insulin.”
“It is proposed that a combination therapy employing some metabolic agents or antioxidants with insulin may constitute an efficacious approach for the prevention of diabetic cardiomyopathy.”
“The antioxidant agents , including catalase and N-acetyl-l-cysteine, could inhibit cardiomyocyte hypertrophy induced by insulin , suggesting that ROS is necessary for insulin to induce hypertrophy.”
“Studies in insulin resistant rodents show an improvement in skeletal muscle insulin sensitivity and oxidative stress following antioxidant supplementation.”
“The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.”
“The improvement of insulin sensitivity by exercise has been shown to be inhibited by supplementation of vitamins acting as antioxidants.”
“Preliminary findings in animal models indicate that rats with insulin resistance show signs of increased lipid peroxidation [12], while the administration of anti-oxidants improves the action of insulin in humans [13-14].”
“ TAOS was negatively correlated with fasting insulin , HOMA-R, CRP, and protein carbonyls.”
“Also, the antioxidant therapy improved insulin sensitivity and glucose tolerance, and in addition, apocynin seemed to prevent the HFD-induced hepatic fat deposition, suggesting an important role of oxidative stress in the induction of NAFLD.”
Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy
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