Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Antioxidants and Indomethacin

supplement:

Antioxidants

Research Papers that Mention the Interaction

Both classical analgesics (nonsteroidal anti-inflammatory drugs, opioid drugs) and … acid can modulate the balance between pro-oxidant and antioxidant processes … indomethacin , meloxicam, tenoxicam, valdecoxib or some metabolites of analgesic drugs formed by the activity of … gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.
Mini reviews in medicinal chemistry  •  2013  |  View Paper
Exposure of Caco-2 and RIE with indomethacin also resulted in a significant reactive oxygen species production that was inhibited by the pretreatment of these cells with antioxidants.
Journal of Gastroenterology  •  2008  |  View Paper
Gene expression of tight junction components such as CLDN1, CLDN2, CLDN7 and OCN and of antioxidant markers such as DUOX2, GPX2, SOD2 were also found to be differentially modulated by EGF and INDO.
Nitric oxide : biology and chemistry  •  2017  |  View Paper
Addition of antioxidants (vitamin C or a green tea polyphenol, epigallocathechin gallate) quenched the ROS and prevented the increase in E. coli internalization and translocation evoked by indomethacin , but not the drop in TER.
American journal of physiology. Gastrointestinal and liver physiology  •  2012  |  View Paper
In serum, only indomethacin administration produced significant increases of the antioxidant protection (P < 0.05).
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2020  |  View Paper
Indomethacin increased the gastric ulcer index, MDA, TNF-α, and decreased PGE2 and non-enzymatic (GSH) and enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) antioxidants.
Journal of Physiology and Biochemistry  •  2013  |  View Paper
The treatments with apocynin, indomethacin and L-NAME reduced the gene expression of antioxidant and oxidant enzymes.
Toxicology letters  •  2011  |  View Paper
Indomethacin caused gastric mucosal injury in the form of haemorrhages, increased the lipid peroxidation and decreased the levels of the antioxidant defense enzymes.
Indian journal of physiology and pharmacology  •  2002  |  View Paper
Antioxidants (tocopherol acetate, essentiale, legalon, flacumin) limit manifestations of indomethacin , hepatotoxicity, as a result of which tha functional-biochemical disorders in the liver show up to a lesser degree.
Farmakologiia i toksikologiia  •  1990  |  View Paper
The results suggest the possibility of potentiation and prolongation of the anti-inflammatory effect of indomethacin by its simultaneous administration with an antioxidant , butylated hydroxyanisole.
Acta biologica et medica Germanica  •  1976  |  View Paper
Show More