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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Indomethacin
Research Papers that Mention the Interaction
“Both classical analgesics (nonsteroidal anti-inflammatory drugs, opioid drugs) and … acid can modulate the balance between pro-oxidant and antioxidant processes … indomethacin , meloxicam, tenoxicam, valdecoxib or some metabolites of analgesic drugs formed by the activity of … gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”
Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress.“Exposure of Caco-2 and RIE with indomethacin also resulted in a significant reactive oxygen species production that was inhibited by the pretreatment of these cells with antioxidants.”
“Gene expression of tight junction components such as CLDN1, CLDN2, CLDN7 and OCN and of antioxidant markers such as DUOX2, GPX2, SOD2 were also found to be differentially modulated by EGF and INDO.”
“Addition of antioxidants (vitamin C or a green tea polyphenol, epigallocathechin gallate) quenched the ROS and prevented the increase in E. coli internalization and translocation evoked by indomethacin , but not the drop in TER.”
“In serum, only indomethacin administration produced significant increases of the antioxidant protection (P < 0.05).”
Daily oral administration of chlorogenic acid prevents the experimental carrageenan-induced oxidative stress.“ Indomethacin increased the gastric ulcer index, MDA, TNF-α, and decreased PGE2 and non-enzymatic (GSH) and enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) antioxidants.”
“The treatments with apocynin, indomethacin and L-NAME reduced the gene expression of antioxidant and oxidant enzymes.”
“ Indomethacin caused gastric mucosal injury in the form of haemorrhages, increased the lipid peroxidation and decreased the levels of the antioxidant defense enzymes.”
“ Antioxidants (tocopherol acetate, essentiale, legalon, flacumin) limit manifestations of indomethacin , hepatotoxicity, as a result of which tha functional-biochemical disorders in the liver show up to a lesser degree.”
“The results suggest the possibility of potentiation and prolongation of the anti-inflammatory effect of indomethacin by its simultaneous administration with an antioxidant , butylated hydroxyanisole.”
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