Possible Interaction: Antioxidants and Hypochlorite

“ AOB acted as a potent peroxyl radical scavenger and suppressed lipid oxidation induced by peroxyl radical, peroxynitrite, hypochlorite , and singlet oxygen, but not by 15-lipoxygenase.”

“In this report, we demonstrate that although Cobl can be an excellent antioxidant , exposure to high levels of HOCl can overcome the beneficial effects of Cobl and generate proinflammatory reaction products.”

“The protection against hypochlorous acid-induced damage provided by antioxidant therapy (vitamins C and E) is of therapeutic significance.”

“ Antioxidant defenses such as reduced glutathione and glucose-6-phosphate dehydrogenase were depleted or inactivated at 10 microM HOCl , while other activities, such as superoxide dismutase, dropped only above 57 microM HOCl.”

“Administration of inhibitors of myeloperoxidase or scavenging hypochlorous acid , the product of myeloperoxidase, by supplementation with antioxidants as an adjuvant therapy may be promising in alleviating the renal side effect of MTX.”

“The effects of HOCl could be blocked by coadministration of antioxidants , i.e., N-acetylcystein (NAC), uric acid (UA) and ascorbic acid (AA).”

“Measurement of elastase activity following PMN activation by PMA showed that antioxidants which reduce H2O2 and/or hypochlorous acid decreased elastase activity.”

“At least four members of the PerR regulon (katA, mrgA, bcp and trxA) encoding proteins with antioxidant properties were strongly induced following exposure to various HOCl concentrations.”

“For the reactions of HOCl with both Trolox and ubiquinol-0, k = 1.3 x 10(3) M(-)(1) s(-)(1); thus, these lipid soluble antioxidants are relatively ineffective as direct scavengers for HOCl as compared to water soluble antioxidants (e.g., ascorbate, k ca.”