Possible Interaction: Antioxidants and Hydroxyurea

“These results suggest that HU directly scavenges free radicals and induces the expression of antioxidant genes via induction of the Nrf2 signaling pathway.”

“For example, free radical scavenging activities of investigated hydroxyureas were higher than the activity of standard antioxidant , butylated hydroxyanisole (BHA).”

“The results suggest that the antioxidant properties of these substances interfere with the rapidly occurring toxic effects of HU and that this may account for amelioration of HU developmental toxicity.”

“Furthermore, while both the antioxidants and HU inhibited T-cell cycling, analysis of a light-scattering parameter related to cell size indicated that the antioxidant-treated cells remained small while the HU-treated and control cells were larger and blast-like.”

“Torres et al. find that SCD plasma has a higher TEAC than control plasma and this TEAC is even higher in SCD patients using HU, suggesting that plasma antioxidant capacity rises in SCD as an adaptation to chronic oxidative stress and that HU further augments antioxidant capacity.”

“The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione).”

“Conclusions These results indicate that hydroxyurea possibly acts as an antioxidant by increasing glutathione levels.”