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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Antioxidants
supplement:
Hydroxocobalamin
Research Papers that Mention the Interaction
“The extensively used thiol antioxidants (dithiothreitol, glutathione, and N-acetylcysteine) in combination with hydroxycobalamine (vitamin B12) gain toxic activity in relation to human lymphocytic leukemia cell line HL60.”
Thiol Antioxidants in Combination with Vitamin B12 Induce Apoptotic Death of Human Lymphocytic Leukemia Cells by Destabilization of Lysosomes with the Involvement of Iron Ions“In this work, we show that thiol antioxidants combined with vitamin B 12b form a prooxidant catalytic system that generates hydrogen peroxide and synergistically induces oxidative stress and apoptotic cell death of tumor cells.”
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