Possible Interaction: Antioxidants and Hydrogen Peroxide

“Treatment of tubular cells with the antioxidant MESNA prior to the addition of H2O2 significantly reduced DNA migration in the comet assay.”

“In mtAQP8‐overexpressed hepatocytes, mitochondrial H2O2 release was found to be increased; and a mitochondria‐targeted antioxidant prevented the upregulation of mitochondrial H2O2 release and that of cholesterol synthesis.”

“The results demonstrated that PD could reverse the accumulation of lipid droplets and production of reactive oxygen species (ROS) induced by H2O2 and increase the expression of antioxidant genes such as NAD(P)H dehydrogenase, quinone 1 (NQO1).”

“ Natural antioxidants and vitamins have potential to protect biological systems from peroxidative damage induced by peroxyl radicals, α-tocopherol (Vitamin E, lipid soluble) and ascorbic acid (vitamin C, water soluble), well known natural antioxidant molecules.”

“The results suggested that QCS–nisin significantly suppressed the growth of both gram-positive bacteria and gram-negative bacteria; The antioxidant effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydroxyl radical and hydrogen peroxide ( H2O2 ) proved to be enhanced with increasing DS and concentration.”

“In the early stage, H2O2 markedly enhanced expression of antioxidant genes and all of the doses used progressively decreased the expression of antioxidant genes in a time-dependent manner.”

“On the other hand, quenching of H2O2 by antioxidants , resveratrol (RSV), or N-acetylcysteine (NAC) effectively blocked TRPM2-mediated Ca2+ influx, decreased intracellular Ca2+ overload, and increased cell survival.”

“By contrast, antioxidants , including vitamin C reduced APAP-induced augmentations in H2O2 levels, but did not inhibit the APAP-induced cytotoxic effects in the hMSCs.”

“Proteomic analysis of three in vitro and two in vivo models revealed a decrease in antioxidant proteins that regulate H2O2 processing, by ≥2 fold in CF vs. matched normal controls.”

“Disappointing results from recent clinical trials with anti-oxidant interventions raise questions about the risks from specific endogenous agents such as hydrogen peroxide and oxy radicals.”