Possible Interaction: Antioxidants and Homocysteine

“In contrast, Hcy suppresses antioxidant gene regulator Nrf2 expression in hearts.”

“Finally, L-homocysteine stimulated O(2)(-) production, which was reversed by antioxidants , and increased SK/IK protein levels and tyrosine nitration in cultured human cardiac microvascular endothelial cells.”

“Numerous neurotoxic effects of Hcy can be blocked by folate, glutamate receptor antagonists, or various antioxidants.”

“The observation that homocysteine also decreases the expression of the antioxidant enzymes glutathione peroxidase and natural killer-enhancing factor B suggests that homocysteine could potentially enhance the cytotoxic effect of agents or conditions known to cause oxidative stress.”

“TOS, Hcy and oxidative DNA damage were negatively correlated with HDL-c, TAS and proteins.”

“ Antioxidant drink vs placebo drink attenuated the tHcy increase in the control group (Tf values of 11.74±0.45 vs 15.63±1.79 μmol/L) and AD patients, especially in the moderate phase (Tf: 10.49±0.73 vs 16.58±2.73 μmol/L).”

“We hypothesized that imbalance of oxidant/antioxidant status and increased Hcy concentration stimulates osteoporotic activity, leading to increased collagen I breakdown in post-menopausal women.”

“However, pretreatment of ECs with antioxidant before Hcy markedly attenuated the induction of DC adhesion and transmigration, dependent on the intracellular ROS decrease and endothelial NO increase.”

“Taken together, our results suggest that ROS is an important mediator of mitochondrial biogenesis induced by Hcy, and that modulation of oxidative stress by antioxidants may protect against the adverse vascular effects of Hcy.”

“In contrast, antioxidants such as catalase, superoxide dismutase and a water-soluble derivative of vitamin E elicit the opposite effect and result in diminished flux of homocysteine through the trans-sulfuration pathway.”