Possible Interaction: Antioxidants and Grape Seed Extract

“ GSE treatment decreased the mitochondrial electron transport chain complex III activity, increased the mitochondrial superoxide levels and depleted the levels of cellular antioxidant (glutathione), thus resulting in the loss of mitochondrial membrane potential in human HNSCC Detroit 562 and FaDu cells.”

“ Grape seed extract (0.02%) has the potential to inhibit oxidative rancidity as well as current synthetic antioxidants.”

“ GSE significantly reduced the LPS-induced intracellular reactive oxygen species (ROS) production and mitochondrial superoxide production, and upregulated the expression of antioxidant enzyme genes.”

“ GPE also markedly increased the antioxidant status of testis.”

“These results suggested that feeding GPE in the early reproductive development stage of lambs upregulated the expression of antioxidative, steroidogenesis, and polyunsaturated fatty acid metabolism-related genes, changed the fatty acid profiles, increased the antioxidant capacity in lamb's testis, and contributed to testis development and spermatogenesis.”

“Taken together, the inclusion of GSE increased final BW and BWG, decreased F/G during day 22 to 42 and day 1 to 42, partially improved antioxidant activities , immunity, meat quality, and gut health in Pekin ducks.”

“RESULTS Antioxidant reductive effects of GSE surpassed those of NAC, lutein, and fish oil containing omega-3 fatty acids.”

“Antioxidant enzymes of rabbits (superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase) and total antioxidant capacity in blood were increased (p ≤ 0.05) by adding dietary GSE.”

“These results suggested that GSPE might potentially prevent HPH via antioxidant and antiproliferative mechanisms.”

“Additionally, grape seed extract GSE ) has been demonstrated to be powerful on antioxidation.”

“ GSE supplementation increased antioxidant enzyme activities in both diabetic and healthy rats (P < 0.05).”