Possible Interaction: Antioxidants and Glutathione

“Encouraging results suggested that loading of anti-oxidants boosted GSH levels and helped to prevent malondialdehyde accumulation and reduce haemolysis.”

“Moreover, the level of plasma GSH was markedly increased only after 2 weeks in patients who received antioxidants.”

“Alpha-lipoic acid is an antioxidant able to increase the levels of intracellular glutathione and eliminate free radicals.”

“The apparent activation of antioxidant defense appeared insufficient as the glutathione and GSH/GSSG ratio were decreased significantly.”

“Upon internalization by HepG2 cells, the strongly electron-withdrawing 2,4-dinitrobenzenesulfonyl groups on the PADEE segments were readily cleaved by ….32) were recovered and completely protonated, leading to disassembly of the micelles and rapid release of PhA. Importantly, the consumption of GSH … antioxidant capacity, resulting in … laser irradiation.”

“Several intracellular antioxidant defense mechanisms including glutathione ( GSH ) and metallothionein (MT) have been shown to minimize As cytotoxicity.”

“Using antioxidants as therapeutic adjuncts could enhance the antioxidant capacity of an inherent glutathione system and overcome oxidative effects, thereby mitigating therapeutic side-effects.”

“Toxicity was associated with enhanced oxidant stress and could be prevented by antioxidants and potentiated if glutathione was removed.”

“ GSH , the most abundant nonprotein thiol in the cell, plays a key role in antioxidant defense.”

“ Antioxidants and caspase inhibitors blocked HT29 cell death whereas glutathione depletion increased it.”