Possible Interaction: Antioxidants and Glutathione Disulfide

“A change in the redox status of blood antioxidants is shown with glutathione oxidation dur ing exercise; this has been observed not only in human blood, but also in animal tissues.”

“RESULTS Antioxidant supplementation was continued during the recuperation week and for a total … supplementation caused a significant increase in plasma vitamins C and E. The an ioxidant su pplementation could inhibit oxidative stress characterized by elevated lipid peroxidation markers … lipid peroxidation as well as reduced ratio of glutathione to oxi dized glutathione pr….”

“All the three antioxidant substances reduced GSSG in both GO and control fibroblasts.”

“However, all three groups showed significant improvements in antioxidant status from baseline to end ( GSSG and dRom levels decreased; GSG:GSSG ratio and ORAC levels increased).”

“However, in B(a)P-incubated cells, SOD inactivation (…<0.05), GR increases (P<0.05), glutathione oxidation (P<0.05) and beta-carotene decreases (…<0.001) showed high disruption of antioxidants , thereby allowing FR-induced damage (i.e. arachidonic acid …, P<0.01; MDA production, P<0.01).”

“Thiol containing antioxidants significantly increased cellular glutathione content while decreasing glutathione disulfide levels.”

“Regarding the hepatic antioxidant function, PT significantly increased total antioxidant capacity (P = 0.007), superoxide dismutase activity (P = 0.016), reduced glutathione content (P = 0.011), and the ratio of reduced glutathione to oxidized glutathione (P = 0.003), whereas it reduced the concentration of oxidized glutathione (P = 0.017).”

“… antioxidants increased basal bile flow (1.37 +/- 0.11 microliter/min per g liver wt) and biliary efflux of total glutathione, i.e. GSH and GSSG , (4.18 +/- 0.97 nmol GSH-eq./min per g) severalfold (up to 250%) over controls 24 h after in vivo antioxidant treatment.”

“Decrease in antioxidants levels accompanying coming down of lipid peroxidation, protein carbonylation, and GSSG :GSH ratio to their lower levels during the post-arousal period showing normalcy in redox status as it was during active period indicates controllability of oxidative stress in hibernating toads.”