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Last Updated: 2 years ago

Possible Interaction: Antioxidants and Gamma-Linolenic Acid

supplement:

Antioxidants

Research Papers that Mention the Interaction

GLA decreased … anti-oxidant content of tumor cells, expression of oncogenes ras, and Bcl-2, enhanced the activity of p53, protected normal cells and tissues from the toxic actions of radiation and anti-cancer drugs, enhanced the cytotoxic action of anti-cancer drugs and reversed tumor cell drug resistance.
In contrast, anti-oxidants such as vitamin E blocked the tumoricidal action of GLA.
Medical science monitor : international medical journal of experimental and clinical research  •  2007  |  View Paper
Gamma-linolenic acid stimulates vasodilator prostanoid production, and there are marked synergistic interactions between gamma-linolenic acid and antioxidants.
Diabetes research and clinical practice  •  1999  |  View Paper
On the other hand, the anti-oxidant , vitamin E, and the superoxide anion quencher, superoxide dismutase (SOD), could completely inhibit the cytotoxic action of GLA , EPA and DHA indicating a role for free radicals and, in particular, the superoxide anion in this process.
Cancer letters  •  1994  |  View Paper
On the other hand, 4 antioxidants (Coenzyme Q, (D) alpha-tocopherol, (DL) alpha-tocopherol, butylated hydroxytoluene) reduced the growth inhibitory effect of GLA , but not in proportion to the decrease of GLA-stimulated lipid peroxidation.
Prostaglandins, leukotrienes, and medicine  •  1986  |  View Paper
Results Dose-dependent treatment of GLA significantly (P<−0.001) modulated the hepatic nodules, hepatic, body weight, antioxidant , and non-hepatic parameters.
Drug design, development and therapy  •  2018  |  View Paper
The difference could be due in part to an antioxidant protective effect of LA on GLA.
The Journal of nutrition  •  2007  |  View Paper