Possible Interaction: Antioxidants and Galactose

“Our results show significant weakened antioxidant defense in HLEC when incubated in the presence of galactose as compared to normal.”

“In addition, … after D-gal administration significantly decreased the expression … factors, enhanced the activities of anti-oxidant enzymes total T-SOD and GSH-px in addition to reducing TNF-α, IL-1β, MDA and … (based on the comparison between the D-gal group and the Rg1 + D-gal group).”

“Our findings lend support to a potential therapeutic strategy for this disease, which may include the use of antioxidants for ameliorating the damage caused by galactose.”

“Data showed that at the pathologically high concentration (greater than 5.0 mM), galactose induces lipid peroxidation, protein carbonylation, alters antioxidant defenses in the cerebrum, and also alters cholinesterase activity.”

“As speculated, the expression of several antioxidant and anti-apoptotic mRNAs has been found to be significantly repressed in the lenses of animals fed a high galactose diet.”

“Further results showed that Forkhead box O3a (FOXO3a), … 2-related factor 2 (Nrf2), and their targeted antioxidants such as superoxide dismutase 2 (SOD2), catalase (CAT), glutathione reductase (GR), glutathione (GSH), glutamate-cysteine … heme oxygenase 1 (HO-1) were all inhibited in the aging rats induced by D-galactose treatment.”

“A. CONCLUSIONS (a) Gal and its derivatives may produce free radicals in the suckling rat brain, reported for first time, (b) Na+,K+ -ATPase … play a protective role reversing the inhibited Na+,K+ -ATPase toward normal in in vitro galactosaemia and (d) the addition of the above antioxidants … Gal ….”

“D being an antioxidant agent plays a vital role in reducing the AD pathophysiology in D-gal induced animal model of aging, therefore act as a potential drug candidate in neurodegenerative diseases.”

“Total antioxidant capacity was significantly negatively correlated with fucose and galactose.”