Possible Interaction: Antioxidants and Folic Acid

“ Folic acid plus antioxidants increased plasma folate by 438% (p < 0.001), reduced plasma homocysteine by 9% (p = 0.56) and insignificantly improved FMD from 2.6 +/- 2.4% to 4.0 +/- 3.7% (p = 0.45), as compared with placebo.”

“According to data obtained from the review, it seems that folic acid supplementation may improve cognitive function by decreasing homocysteine (Hcy), vascular care, attenuating inflammatory status, modification of cerebral folic acid deficiency, and antioxidant responses.”

“Our results … enterocytes with LS prevents membrane barrier disruption and cellular reactive oxygen species (ROS) …, modulates the expression of the gastro-intestinal glutathione peroxidase (GPX2) antioxidant enzyme, and reduces p65 phosphorylation, supporting the involvement of the Nfr2 and … B pathways in the activation of antioxidant cellular defenses by probiotics.”

“Moreover, other antioxidants have been shown to improve insulin resistance and obesity in FA mice [7] and to restore the metallo-proteinases activity in FA cells thus suggesting a possible role of oxidative stress in the glucose and lipid metabolic disturbance and in somatic malformations [8].”

“Studies have shown that lower levels of antioxidants coexisting with low levels of folic acid increases the risk of CIN development.”

“In conclusion, the combination of AA and FA at 200 and 1.5 mg/kg, respectively, increased the broilers’ antioxidant status with coordinated improvement in the growth performance and health status under HS.”

“Given downregulation of Tgfb1 expression by folic acid, antioxidant Tempol reversed DNA demethylation, with increased and decreased recruitment of DNMT1 and USF1 to the promoter, resulting in decreased Tgfb1 expression in db/db mice.”

“These data indicated that deficient folic acid diet damaged fish intestinal antioxidant capacity partly by regulating Nrf2/Keap1 pathway.”

“It has also been demonstrated that folic acid increases GSH levels, improving the antioxidant status and revealing a hepatoprotective effect during binge drinking.”

“Treatment with methyl donors (vitamin B12, folic acid , choline) had no protectant effect and actually enhanced the cell loss evoked by TSE; they did have a minor, synergistic interaction with antioxidants protecting against TSE effects on growth.”