supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Antioxidants
supplement:
Fluorides
Research Papers that Mention the Interaction
“Thus, in the absence of clear proof of oxidative damage and to counter toxic effects of fluoride through supplementation of antioxidants , extensive investigations are needed to conclusively prove the role of oxidative stress in skeletal fluorosis.”
Antioxidant defense system and lipid peroxidation in patients with skeletal fluorosis and in fluoride-intoxicated rabbits.“ Fluoride coincubated with NAC ( antioxidant ) dramatically decreased ROS and LDH levels compared with the fluoride only group (in the test level of 0.05, the difference were statistical significance).”
“Interestingly, antioxidants (vitamin E and glutathione) can attenuate the inhibition of the receptor induced by fluoride.”
“Prior treatment with antioxidant resulted in preventing the decrease of nAChR protein in cells exposed to the high doses of fluoride.”
“The results of this study showed that F- affects antioxidant enzymes activity, COX2 protein expression and PGE2 synthesis in liver.”
Pre-and postnatal exposition to fluorides induce changes in rats liver morphology by impairment of antioxidant defense mechanisms and COX induction.“In addition, upon administration of Fl significantly (p<0.05) decreased the antioxidant status , Nrf2, and HO-1 with increased Keap1 protein.”
“A significant decrease in the levels of enzymatic (SOD2, CAT, GPx, and GSTpi class) and nonenzymatic (GSH and Vitamin C) antioxidants along with increased ROS, lipid peroxidation, protein carbonyl content, and nitrate levels by fluoride were also prevented in these groups.”
“The severity of fluoride toxicity was reduced by oral administration of certain plant derived antioxidants.”
“ Fluoride induced oxidative stress through depletion in levels of various anti‐oxidants such as glutathione, superoxide dismutase (SOD), fat soluble vitamins (D and E) with increased levels of lipid peroxidation (LPO) and fluoride aggravate the damage in rodents as well as in humans.”
“Sub-… to fluoride at a dose of 20mg/kgb.w./… 30 days caused significant alteration in pro-oxidant/anti-oxidant status of brain tissue as reflected by perturbation of reduced glutathione content, increased lipid peroxidation, … carbonylation, nitric oxide and free hydroxyl radical production and decreased activities of antioxidant enzymes.”
“However, it seems that at the dosage used, fluoride toxicity may be a direct effect on the antioxidant enzymes.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback