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“Such an inhibitory effect of 4HPR was abolished by antioxidants and by inhibitors of 12-lipoxygenase, baicalein (specific) and esculetin (panspecific).”
“In this study we show that addition of antioxidants to HL-60 cells cultured in the presence of 3 microM HPR , markedly suppresses the apoptopic effect of the retinoid and significantly prolongs cell survival (48-96 h).”