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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Antioxidants
drug:
Fenretinide
Research Papers that Mention the Interaction
“Such an inhibitory effect of 4HPR was abolished by antioxidants and by inhibitors of 12-lipoxygenase, baicalein (specific) and esculetin (panspecific).”
ROS mediates 4HPR-induced posttranscriptional expression of the Gadd153 gene.“All these 4HPR's effects, as well as the induction of apoptosis, were inhibited by antioxidants , which decrease ROS.”
“We found that 4HPR induced apoptosis in all of the cell lines; however, this effect was blocked by antioxidants in only 2 of the 10 cell lines.”
“In this study we show that addition of antioxidants to HL-60 cells cultured in the presence of 3 microM HPR , markedly suppresses the apoptopic effect of the retinoid and significantly prolongs cell survival (48-96 h).”
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