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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Exenatide
Research Papers that Mention the Interaction
“The results have demonstrated that exenatide can exert its beneficial and protective effects by elevating the levels of endogenous antioxidants and genes responsible for the survival, regeneration and proliferation of pancreatic β-cell.”
Mechanism of the beneficial and protective effects of exenatide in diabetic rats.“ EX4 increases antioxidant gene expression.”
EX4 stabilizes and activates Nrf2 via PKC&dgr;, contributing to the prevention of oxidative stress‐induced pancreatic beta cell damage“Here we report that Exendin-4 triggered Nrf2 nuclear translocation, a downstream target of cAMP-responsive element-binding protein (CREB) and expressions of antioxidant genes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase-1 (NQO-1) in a dose- and time-dependent manner.”
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