“Metabolomic analysis showed that the metabolic processes responsible for antioxidant defence … by NET (e.g. upregulation of nervonyl carnitine and chenodeoxycholic acid 3-sulfate ; downregulation of homolanthionine and … these changes can undermine antioxidant defence by suppressing Nrf2-ARE and NF-κB pathways … to the synthesis of SOD and GSH.”