Possible Interaction: Antioxidants and Erdosteine

“Experimental data in animal assigned to receive … agent evidence that co-treatment with erdosteine increases … tissue antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase, compared with the toxic agent alone; … erdosteine decreases the tissue level of nitric oxide, xanthine oxidase, which catalyze oxygen-free radical production.”

“In summary, erdosteine prevents the accumulation of free oxygen radicals when their production is accelerated and increases antioxidant cellular protective mechanisms.”

“ Erdosteine markedly induces expression of NF-E2-related factor 2 (Nrf2), which may contribute to the increase in expression of glutathione …-glutamate-l-cysteine-ligase catalytic and γ-l-glutamate-l-cysteine-ligase modifier subunits, as well as in the antioxidant genes HO-1 and SOD2 … HEI-OC1 cells.”

“Both erdosteine and ebselen alone significantly decreased MDA, PCC, and NO(x) levels and increased antioxidant enzymes activities, but all values were different from control.”

“Furthermore, erdosteine administration led to an increase in antioxidant enzyme activities in comparison with the control group.”